Journal article
Staging in bipolar disorder: from theoretical framework to clinical utility
M Berk, R Post, A Ratheesh, E Gliddon, A Singh, E Vieta, AF Carvalho, MM Ashton, L Berk, SM Cotton, PD McGorry, BS Fernandes, LN Yatham, S Dodd
World Psychiatry | WILEY | Published : 2017
DOI: 10.1002/wps.20441
Abstract
Illness staging is widely utilized in several medical disciplines to help predict course or prognosis, and optimize treatment. Staging models in psychiatry in general, and bipolar disorder in particular, depend on the premise that psychopathology moves along a predictable path: an at-risk or latency stage, a prodrome progressing to a first clinical threshold episode, and one or more recurrences with the potential to revert or progress to late or end-stage manifestations. The utility and validity of a staging model for bipolar disorder depend on its linking to clinical outcome, treatment response and neurobiological measures. These include progressive biochemical, neuroimaging and cognitive c..
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Awarded by National Institute of Mental Health
Funding Acknowledgements
M. Berk is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (1059660). E. Vieta is supported by the Spanish Ministry of Economy and Competitiveness (PI15/00283) integrated into the Plan Nacional de I1D1I and co-funded by ISCIII-Subdireccion General de Evaluacion y el Fondo Europeo de Desarrollo Regional, CIBERSAM, and the Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya (2014 SGR 398). S.M. Cotton is supported by a NHMRC Career Development Fellowship (APP1061998). P.D. McGorry is supported by a Senior Principal Research Fellowship from NHMRC Australia (ID: 1060996) and currently receives research support from the Colonial Foundation, National Institute of Mental Health, Stanley Medical Research Institute and the BROAD Institute.